Urticarial vasculitis: An autoimmune disorder following therapy for Hodgkin's disease
Identifieur interne : 002B34 ( Main/Exploration ); précédent : 002B33; suivant : 002B35Urticarial vasculitis: An autoimmune disorder following therapy for Hodgkin's disease
Auteurs : Donald K. Strickland [États-Unis] ; Russell E. Ware [États-Unis]Source :
- Medical and Pediatric Oncology [ 0098-1532 ] ; 1995-09.
English descriptors
- Teeft :
- Abnormal numbers, Abnormality, Antibody response, Autoimmune, Autoimmune disease, Autoimmune disorder, Autoimmune process, Biopsy, Cell function, Clinical course, Corticosteroid, Dapsone, Dysregulation, Engl, Erythrocyte sedimentation rate, Idiopathic thrombocytopenic purpura, Immune, Immune abnormalities, Immune complexes, Immune dysfunction, Immune dysregulation, Immune system, Immunization, Inguinal lymph nodes, Lymph, Lymph node biopsy, Lymphadenopathy, Lymphocyte, Lymphocyte counts, Lymphocyte enumeration, Malignancy, Mediastinal, Neutrophil, Node, Nonsteroidal antiinflammatory drugs, Posttherapy, Rash, Recurrent disease, Serum copper, Siber, Skin biopsies, Skin biopsy, Strickland, Systemic symptoms, Urticaria1 vasculitis, Urticarial, Urticarial vasculitis, Vasculitis.
Abstract
Immunological abnormalities have been described in patients with Hodgkin's disease, both associated with the malignancy itself and occurring secondary to therapy. These abnormalities often manifest as an immunodeficiency state, but can also present as immune dysregulation and autoimmune disease. We report two young patients with Hodgkin's disease who, following successful therapy, developed urticarial vasculitis (UV), a form of cutaneous autoimmune vasculitis. Both patients also had systemic symptoms including fever, an elevated erythrocyte sedimentation rate and serum copper, and abnormal in vitro studies of lymphocyte enumeration and proliferation. Distinguishing UV from recurrent Hodgkin's disease was especially difficult in one patient, and was possible only by lymph node biopsy. One patient has responded well to immunosuppressive therapy, while the other, who has more profound immune dysfunction, has developed a chronic autoimmune disorder. UV may thus occur in patients after therapy for Hodgkin's disease; we hypothesize that immune dysregulation, either associated with the malignancy or resulting from therapy, is important in the pathogenesis of this autoimmune process. © 1995 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/mpo.2950250309
Affiliations:
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These abnormalities often manifest as an immunodeficiency state, but can also present as immune dysregulation and autoimmune disease. We report two young patients with Hodgkin's disease who, following successful therapy, developed urticarial vasculitis (UV), a form of cutaneous autoimmune vasculitis. Both patients also had systemic symptoms including fever, an elevated erythrocyte sedimentation rate and serum copper, and abnormal in vitro studies of lymphocyte enumeration and proliferation. Distinguishing UV from recurrent Hodgkin's disease was especially difficult in one patient, and was possible only by lymph node biopsy. One patient has responded well to immunosuppressive therapy, while the other, who has more profound immune dysfunction, has developed a chronic autoimmune disorder. UV may thus occur in patients after therapy for Hodgkin's disease; we hypothesize that immune dysregulation, either associated with the malignancy or resulting from therapy, is important in the pathogenesis of this autoimmune process. © 1995 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Missouri (État)</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Strickland, Donald K" sort="Strickland, Donald K" uniqKey="Strickland D" first="Donald K." last="Strickland">Donald K. Strickland</name></region><name sortKey="Strickland, Donald K" sort="Strickland, Donald K" uniqKey="Strickland D" first="Donald K." last="Strickland">Donald K. Strickland</name><name sortKey="Ware, Russell E" sort="Ware, Russell E" uniqKey="Ware R" first="Russell E." last="Ware">Russell E. Ware</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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